External factors
| External factors: |
Doxycycline |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Western blot |
| Description: |
Doxycycline treatment resulted not only in a strong induction of RasG12V, but concomitantly induced senescence alterations including increased p21 expression, SA-β-gal activity and the characteristic pHP1c staining . |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Target gene experiment: |
qRT-PCR |
| Target gene description: |
The expression of the senescence markers was again associated with a strongly increased IkBζ expression. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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