External factors
| External factors: |
HDAC inhibitor(sodium butyrate(NaBu) and valproic acid(VPA)) |
| Category: |
Chemical compounds |
| Tissue type: |
Blood,Adipose |
| Cell name: |
AD-MSC,UCB-MSC |
| Experiment: |
SA-β-gal activity assay |
| Description: |
We extended the treatment period up to 7 days, where we observed tha MSCs acquired a senescent phenotype based on SA-β-gal staining. |
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Regulatory relationship
| Target gene:
|
JMJD3//P16//SUZ12//BMI1//EZH2//C-MYC |
| R-EF-Target gene:
|
Upregulation//Upregulation//Downregulation//Downregulation//Downregulation//Downregulation |
| Official symbol(s): |
KDM6B//P16//SUZ12//BMI1//EZH2//C-MYC |
| Target gene experiment: |
RT-PCR//Western blot |
| Target gene description: |
hUCB- and hADMSCs showed decreased expression of c-MYC, BMI1 and SUZ12. JMJD3 was upregulated by 1-day treatment of HDAC inhibitors, and its expression level peaked at 3 days of treatment. p16INK4Awas slightly increased from 3 days of treatment of HDAC inhibitors. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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