External factors
| Category: |
Chemical compounds |
| Experimental category: |
HL |
| Experiment: |
SA-β-gal activity assay//Telomerase activity assay |
| Description: |
The percentage of positive SA-β-gal staining cells was increased, the telomerase activity was decreased and the expressions (both mRNA and protein) of both CGRP I and Klotho were down-regulated in Ang II-treated EPCs. Pretreatment with rutaecarpine reversed these effects in a dose-dependent manner. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
KLOTHO |
| Target gene experiment: |
Western blot//PCR |
| Target gene description: |
AngII was able to accelerate EPCs senescence as shown by the decrease in the expression of both Klotho mRNA and secreted Klotho protein,The effect was reversed by exogenous administration of RUT in a dose-dependent manner. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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