External factors
| Category: |
Chemical compounds |
| Experimental category: |
HL |
| Experiment: |
SA-β-gal activity assay//Telomerase activity assay |
| Description: |
AngII was able to accelerate EPCs senescence as shown by the increased percentage of positive SA-β-gal staining cells and the decreased telomerase activity concomitantly with the increase in the mRNA expression of NADPH oxidase gp91phoxsubunit and intracellular ROS production shown by fluorescent dichlorofluorescein.These effects were reversed by exogenous administration of CGRP in a dose-dependent manner. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
KLOTHO |
| Target gene experiment: |
Western blot//PCR |
| Target gene description: |
AngII was able to accelerate EPCs senescence as shown by the decrease in the expression of both Klotho mRNA and secreted Klotho protein,The effect was reversed by exogenous administration of CGRP in a dose-dependent manner. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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