External factors
| Category: |
Chemical compounds |
| Experimental category: |
HL |
| Experiment: |
SA-β-gal activity assay//Telomerase activity assay |
| Description: |
AngII was able to accelerate EPCs senescence as shown by the increased percentage of positive SA-β-gal staining cells and the decreased telomerase activity concomitantly with the increase in the mRNA expression of NADPH oxidase gp91phoxsubunit and intracellular ROS production shown by fluorescent dichlorofluorescein. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
KLOTHO |
| Target gene experiment: |
Western blot//PCR |
| Target gene description: |
AngII was able to accelerate EPCs senescence as shown by the decrease in the expression of both Klotho mRNA and secreted Klotho protein. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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