External factors
| External factors: |
Rapamycin |
| Category: |
Chemical compounds |
| Phenotype: |
Werner syndrome |
| Experiment: |
Western blot//Immunochemical staining |
| Description: |
At the end of 42 days, growth rates reached 1.3 population doubling (PD) per week for WRN knockdown cells with rapamycin compared with 0.4 PD per week without rapamycin. Moreover, long-term rapamycin treatment restored normal nuclear morphology of WRN knockdown fibroblasts. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation//Downregulation |
| Official symbol(s): |
MAP1LC3A//P62 |
| Target gene experiment: |
Western blot |
| Target gene description: |
Rapamycin induced increases in LC3-II and decreases in p62, consistent with enhanced degradation of autophagosomes. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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