External factors
| External factors: |
UNC2025 |
| Category: |
Chemical compounds |
| Cell name: |
A172,SF188,U251 |
| Experiment: |
Cell Cycle analysis//Flow cytometry//SA-β-gal activity assay//BrdU assay//PI staining |
| Description: |
The amount of BrdU incorporation significantly decreased following UNC2025 treatment, indicating decreased proliferation in SF188 and U251 cells, while only a trend of decreased proliferation was observed in A172;treatment of A172, SF188, and U251 cells with UNC2025 induced beta-galactosidase activity (blue staining), a prominent marker of senescence.[25] .At a molecular level, p16 and p21 are markers of senescence [24]. |
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Regulatory relationship
| Official symbol(s): |
MERTK |
| Target gene experiment: |
Densitometry analysis//Western blot |
| Target gene description: |
Afterone hour of UNC2025 treatment, MERTK phosphorylationwas reducedin all three celllines and in a dosedependentmanner. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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