External factors
| External factors: |
Simvastatin |
| Category: |
Chemical compounds |
| Phenotype: |
Atherosclerosis |
| Experiment: |
SA-β-gal activity assay//qPCR//Western blot |
| Description: |
When HUVECs were treated with TNF-α together with valsartan or simvastatin, miR-155 expression was significantly reduced, accompanied by a parallel upregulation in SIRT1 expression and a decrease in TNF-α-induced HUVEC senescence . |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
MIR-156 |
| Target gene experiment: |
qPCR//Western blot |
| Target gene description: |
When HUVECs were treated with TNF-α together with valsartan or simvastatin, miR-155 expression was significantly reduced, accompanied by a parallel upregulation in SIRT1 expression . |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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