External factors
| External factors: |
Radiation |
| Experiment: |
CCK-8 assay//SA-β-gal activity assay//qRT-PCR//Cell proliferation assay |
| Description: |
Radiation markedly inhibited cellular proliferation and increased the expression levels of the cellular senescence?associated genes Cdkn1a and Cdkn2c.Radiation exposure also significantly shortened the relative telomere length, impaired the relative telomerase activity and increased the percentage of SA?β?gal?positive cells. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
MIR-34A |
| Target gene experiment: |
qRT-PCR |
| Target gene description: |
miR?34a expression levels in HCMs were significantly increased following exposure to radiation. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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