External factors
| Category: |
Chemical compounds |
| Experiment: |
CCK-8 assay//SA-β-gal activity assay//RT?qPCR |
| Description: |
MIF treatment in cells exposed to radiation increased cellular proliferation, decreased the expression levels of the senescence?associated genes Cdkn1a and Cdkn2c , recovered the impaired relative telomere length and activity ,and reduced the percentage of SA?β?gal?positive cells. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
MIR-34A |
| Target gene experiment: |
qRT-PCR |
| Target gene description: |
Exogenous MIF significantly decreased the expression of miR?34a induced by radiation. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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