External factors
| External factors: |
Lithium |
| Phenotype: |
Cardiovascular disease |
| Experiment: |
SA-β-gal activity assay |
| Description: |
Lithium treatment for 5 days increased 4.5- fold the number of SA-β-galactosidase positive cells as compared with sodium-treated control cells. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation//Upregulation |
| Official symbol(s): |
MMP1//SERPINE1 |
| Target gene experiment: |
qRT-PCR |
| Target gene description: |
Lithium treatment for 24 h resulted in a significant 13-fold increase of MMP-1 and a 2.7-fold increase of PAI-1 mRNA levels. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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