External factors
| External factors: |
Embonic acid |
| Experiment: |
SA-β-gal activity assay |
| Description: |
EA treatment caused a profound increase in the expression of senescence-associated β-galactosidase by H1299 cells. In the absence of EA, the senescent signal,SA-β-gal+ H1299 cells, was not present . |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
M-NAD(P)-ME |
| Target gene experiment: |
In vitro analysis |
| Target gene description: |
By in vitro testing of a chemical compound library, we found a natural chemical, EA, which can inhibit m-NAD(P)-ME much more potently than c-NADP-ME. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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