External factors
| External factors: |
Nicotinamide mononucleotide |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//qPCR//Western?blot |
| Description: |
The number of β-galacto-sidase positive cells was also decreased in cultures exposed to NMN .Additionally, the compound prevented FK866-induced RPE senescence as indicated by the suppression of p16INK4a and p21Waf/Cip1 expression and the reduction of SIRT1 expression . |
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Regulatory relationship
| R-EF-Target gene:
|
Upregulation//Upregulation |
| Official symbol(s): |
NAD//SIRT1 |
| Target gene experiment: |
qPCR//Western?blot |
| Target gene description: |
NMN dose-dependently enhanced NAD+ levels in cells exposed to FK866 .Importantly, NMN also prevented the FK866-induced decrease in SIRT1 expression. |
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
471
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
472
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 751
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 754
Warning: Undefined variable $pathway_id in /data/html/Aging-ReG/public/browse_detail_2.php on line 793