External factors
| Category: |
Chemical compounds |
| Phenotype: |
Retinal disease |
| Experiment: |
SA-β-gal activity assay//qPCR//Western?blot |
| Description: |
β-galactosidase staining and related quantification revealed a time-dependent increase in the number of β-gal-positive cells in FK866-treated cultures .Similarly, the expression of p21Waf/Cip1, p16INK4a, ApoJ and CTGF was increased and SIRT1 expression and activity decreased time-dependently. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation//Downregulation |
| Official symbol(s): |
NAD//SIRT1 |
| Target gene experiment: |
SA-β-gal activity assay//qPCR//Western?blot |
| Target gene description: |
Congruent with β-galactosidase staining, the expression of each of these markers was increased in association with increasing concentrations of FK866 and the associated decline in NAD+ . Additionally, the expression and activity of SIRT1 was dose-dependently decreased . |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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