External factors
| External factors: |
Galangin |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity//MTT assay//Western blot |
| Description: |
HS68 cells were pretreated with galangin (30 lM) for 1 hour followed by incubation with H2O2 (200 lM) for 24 hours prior to SA-β-gal staining. We found that H2O2 significantly increased the number of senescent cells (green) as compared with the control. These data demonstrate that galangin can significantly inhibit H2O2-induced cell senescence .The MTT assay results showed that galangin dosedependently increased the viability of H2O2-induced HS68 cells. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
NF-KB |
| Target gene experiment: |
Western blot |
| Target gene description: |
The data demonstrated that galangin reduced the levels of H2O2-induced inflammation-related proteins, IL6, TNF-a, IL-1b, and p-NF-jB p65 . |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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