External factors
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Flow cytometry |
| Description: |
After coincubation with Ang II (200 nmol/L) for 24 h, the number of SA-β-Gal-positive or G0/G1 resting cells increased significantly. |
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Regulatory relationship
| Target gene:
|
NOX2//NOX4//NOX5 |
| R-EF-Target gene:
|
Upregulation//Upregulation//Upregulation |
| Official symbol(s): |
CYBB//NOX4//NOX5 |
| Target gene experiment: |
RT-PCR//Western blot |
| Target gene description: |
Results in late EPCs treated with Ang II, revealed that differential expression of NOX mRNA existed. Within 5 kinds of NOX mRNA, NOX2, NOX4 and NOX5 mRNA levels were significantly increased.Similarly, in Western blot,Ang II (200nmol/L) resulted in maximum increase in NOX5 protein level at 3h versus NOX2 and NOX4 at 12h. However, siRNA targeting NOX2 or NOX4 yielded a significant decrease in SA-β-Gal positive or G0/G1 resting cells. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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