External factors
| External factors: |
High glucose |
| Experiment: |
SA-β-gal activity assay//Western blot//SAHF |
| Description: |
The expressions of senescence-associated markers, including P16, P21, cell membrane DcR2, cytoplasmic SA-β-Gal activity, nuclear formation of SAHF, were increased significantly at 48?h in HG-treated RTECs. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Target gene experiment: |
Western blot//SA-β-gal activity assay |
| Target gene description: |
OPTN siRNA assay showed that silencing of OPTN gene significantly inhibited HG-induced mitophagosome formation and enhanced RTEC senescence . |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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