External factors
| Category: |
Chemical compounds |
| Tissue type: |
Mammary Gland |
| Experiment: |
SA-β-gal activity assay |
| Description: |
NAX014 and, to a lesser extent, BBR administration increased the number of cells with a senescent-like phenotype in mammary tumor samples, as evidenced by the increased SA-β-gal staining. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Target gene experiment: |
qRT-PCR |
| Target gene description: |
NAX014 induced a significant dose-dependent upregulation of p16INK4a mRNA level. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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