External factors
| Category: |
Chemical compounds |
| Phenotype: |
Cystic Fibrosis |
| Description: |
These results suggest that NE may activate airway epithelial senescence in CF via p16-mediated inhibition of CDK4 and failure of phospho-Rb-triggered DNA synthesis.NE treatment injured the epithelial monolayer in a dose-dependent manner. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation//Downregulation |
| Official symbol(s): |
P16//CDK4 |
| Target gene experiment: |
Western blot//Kinase assay |
| Target gene description: |
Western analyses demonstrated a significant increase in p16 protein expression in response to NE treatment；NE treatment significantly decreased phosphorylation of Rb, the substrate for CDK4 activity . |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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