External factors
| External factors: |
Teng-Long-Bu-Zhong-Tang |
| Category: |
Chemical compounds |
| Phenotype: |
Colorectal cancer |
| Experiment: |
SA-β-gal activity assay |
| Description: |
TLBZT treatment resulted in significant cell senescence in CT26 colon carcinoma compared with controls (P<0.01). |
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Regulatory relationship
| Target gene:
|
P16//P21//RB |
| R-EF-Target gene:
|
Upregulation//Upregulation//Downregulation |
| Official symbol(s): |
P16//P21//RB |
| Target gene experiment: |
Western blot//Immunohistochemistry |
| Target gene description: |
We examined p16, p21 and RB phosphorylation in CT26 colon carcinoma after three weeks of TLBZT treatment by immunohistochemistry and western blot.TLBZT significantly upregulated p16 and p21 expression, and downregulated RB phosphorylation in CT26 colon carcinoma and compared with controls (P<0.01). |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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