External factors
| Category: |
Chemical compounds |
| Phenotype: |
Hepatocellular carcinoma |
| Experimental category: |
HL |
| Experiment: |
Knockdown//SA-β-gal activity assay//BrdU assay |
| Description: |
Knockdown of Arid1b blunted replicative senescence,as evidenced by increased colony formation, a higher percentage of cells incorpo- rating BrdU, and a decrease in the percentage of senescence-associated β-galactosidase (SA-β-Gal)-positive cells when compared with control MEFs. |
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Regulatory relationship
| Target gene:
|
P16//P21A//P53 |
| R-EF-Target gene:
|
Upregulation//Upregulation//Upregulation |
| Official symbol(s): |
P16//P21A//P53 |
| Target gene experiment: |
DAPI staining//IF |
| Target gene description: |
Indeed, the expression of ARID1B not only induced p16INK4a and p21CIP1a but also up-regulated p53 levels and caused DNA damage and oxidative stress . |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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