External factors
| External factors: |
BI-D1870 |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Knockdown |
| Description: |
BI-D1870 almost completely prevented γIR-induced apoptosis of p53-deficient HCT116 cells and, similar to U0126, produced the senescent phenotype in both wild-type and p53-deficient cells regardless of whether or not they were irradiated. BI-D1870 also induced senescence in MCF-7/casp3 breast carcinoma cells, indicating a more general response to this compound . |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Target gene experiment: |
Western blot |
| Target gene description: |
Therefore, we analyzed p21 expression in BI-D1870-treated cells and found that this compound induced a substantial p21 accumulation in HCT116 wild-type cells albeit to a lesser extent compared with γIR .Interestingly, BI-D1870-mediated p21 accumulation appears to occur independently of p53 that was only stabilized following γIR, but not in response to BI-D1870.Consistent with our observation that BI-D1870 was able to induce senescence in MCF-7/casp3 cells as well, this event was also accompanied by p21 upregulation. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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