External factors
| Category: |
Chemical compounds |
| Phenotype: |
Cervical cancer |
| Experiment: |
SA-β-gal activity assay |
| Description: |
C3 cells expressing hTERTC27 exhibited a significantly reduced growth rate after the H2O2 challenge compared to the control EGFP expressing A1 cells. Furthermore, at 7 days after H2O2 treatment, the C3 cells became enlarged and flattened, lost cell-to-cell contact, and stained positively forSA β-gal. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Target gene experiment: |
Western blot |
| Target gene description: |
Western blot analysis showed that in C3 cells, a sustained increase of p21Waf1 protein level was observed from day 1 to at least day 9. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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