External factors
| External factors: |
Pioglitazone and Melatonin |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
We investigated the inhibitory effects of pioglitazone and melatonin on MSC senescence induced by IS. The combination therapy of pioglitazone and melatonin significantly reduced IS-induced increase of SA-β-gal activity. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Target gene experiment: |
Western blot |
| Target gene description: |
Pioglitazone?and?melatonin?ameliorated?the?IS‐induced?reduction?in?SMP30?expression?and?inhibited?the?increase in p21. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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