External factors
| External factors: |
AMG 900+HDACI |
| Category: |
Chemical compounds |
| Phenotype: |
Prostate cancer |
| Experiment: |
SA-β-gal activity assay//Cell morphological analysis |
| Description: |
Treated cells displayed a flattened morphology compared to untreated controls, and some treated DU-145 and PC3 cells showed cytoplasmic vacuoles and granularity.Consistent with our previously observed morphological transformations, DU-145 and PC3 cells treated with combinations of AMG 900 and HDACIs had increased SA β-galactosidase staining. LNCaP cells had a baseline level of blue SA β-galactosidase staining in untreated controls; combination treatment of LNCaP cells with AMG 900 and HDACIs resulted in increased SA β-galactosidase staining. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Target gene experiment: |
Western blot |
| Target gene description: |
Combination treatment further increased p21 levels, suggesting increased cellular senescence. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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