External factors
| External factors: |
Argentatin B |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
SA-β-gal activity assay:After incubation with argentatin B for 72 h, both cell lines exhibited phenotypic changes that resemble those observed in cells undergoing senescence, such as flattened morphology and enlarged cell size.When tested for senescence associated-β-galactosidase activity, a proportion of 43% HCT-15, and 66% PC-3 cells showed a positive staining, compared with 2% of untreated controls. These findings suggest that argentatin B inhibits cell proliferation by inducing senescence. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation//Upregulation |
| Official symbol(s): |
P21//P27 |
| Target gene experiment: |
Western blot |
| Target gene description: |
Treatment with argentatin B induced an increment of both, p21 and p27 in PC-3 cells after 48 h incubation, and it was persistent for at least 72 h after treatment. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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