External factors
| External factors: |
Simvastatin |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Histological staining//Multiplex cytokine assay |
| Description: |
Cotreatment of tissues with both simvastatin and rosuvastatin reduced the number of SA- β- Gal staining cells to that seen in controls, suggesting that a reduction in p38MAPK activation decreased senescence .Cotreatment of fetal membranes with CSE + S100 and CSE + S200 led to lower levels of GM- CSF and TNF- α. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
P38MAPK |
| Target gene experiment: |
Western blot |
| Target gene description: |
Cotreatment of CSE with simvastatin (CSE 155 ± 10.17, CSE + S100 = 108.9 ± 32.54, CSE + S200 = 76.79 ± 14.13, all P < .05) and rosuvastatin (CSE = 155 ± 10.17, CSE + R100 = 88.29 ± 9.177, CSE + R200 = 85.49 ± 5.77, all P < .05) significantly decreased p38MAPK activation compared to CSE. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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