External factors
| External factors: |
Irradiation |
| Phenotype: |
Prostate cancer |
| Experiment: |
SA-β-gal activity assay//Flow cytometry |
| Description: |
In contrast, an equivalent dose of IR (4 Gy) induced SA-β-gal expression in approximately 75% of the LNCaP cells and 50% of the 22Rv1 cells.increased the proportion of senescent cells 5 days after IR. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Target gene experiment: |
Western blot |
| Target gene description: |
IR (6 Gy) was sufficient to induce a rapid (<30 min) and sustained (>180 min) phosphorylation of p53 (at Ser15) by kinases such as ATM .In contrast, both the accumulation of p53 protein and transactivation of its downstream target, p21, were consistently delayed and more persistent in 22Rv1 cells. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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