External factors
| External factors: |
Formaldehyde |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//EdU assay//Western blot |
| Description: |
We found that the ability of FA-treated IMR90 cells to enter into stable replication arrest, and senescence was completely dependent on p53. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Target gene experiment: |
Western blot |
| Target gene description: |
Stress-responsive phosphorylation of p53 at Ser15 was already detectable after a 30-min-long FA treatment and increased further at longer 1–3 h exposures . Ser15 phosphorylation and p53 protein levels continued to increase for several hours after FA removal. At 6 h post-exposure, a strong phosphorylation at Ser15 was observed with as low as 50 μM FA, which is within its physiological concentration range in human serum.22. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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