External factors
| External factors: |
Metformin |
| Category: |
Chemical compounds |
| Phenotype: |
Colorectal cancer |
| Experiment: |
SA-β-gal activity assay//qRT-PCR |
| Description: |
In the present study, we found that the metformin/ABT-263 cotreatment induced an obvious cellular senescence in HCT-116 p53+/+ cells, whereas the cotreatment only slightly evoked the cellular senescence in HCT-116 p53?/? cells.In the present study, we found that the metformin/ABT-263 cotreatment induced an obvious cellular senescence in HCT-116 p53+/+ cells, whereas the cotreatment only slightly evoked the cellular senescence in HCT-116 p53?/? cells.ABT-263 significantly increased most of them, which was augmented by metformin in HCT-116 p53+/+ cells. However, these SASP components were unchanged or just mildly increased upon metformin/ABT-263 cotreatment in HCT-116 p53?/? cells. |
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
383
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Regulatory relationship
| Target gene experiment: |
SA-β-gal activity assay |
| Target gene description: |
We found that the metformin/ABT-263 cotreatment induced an obvious cellular senescence in HCT-116 p53+/+ cells, whereas the cotreatment only slightly evoked the cellular senescence in HCT-116 p53?/? cells. |
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
471
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
472
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 751
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 754
Warning: Undefined variable $pathway_id in /data/html/Aging-ReG/public/browse_detail_2.php on line 793