External factors
| External factors: |
ABT-263 |
| Category: |
Chemical compounds |
| Phenotype: |
Colorectal cancer |
| Experiment: |
SA-β-gal activity assay//qRT-PCR |
| Description: |
In the present study, we found that the metformin/ABT-263 cotreatment induced an obvious cellular senescence in HCT-116 p53+/+ cells, whereas the cotreatment only slightly evoked the cellular senescence in HCT-116 p53?/? cells.In the present study, we found that the metformin/ABT-263 cotreatment induced an obvious cellular senescence in HCT-116 p53+/+ cells, whereas the cotreatment only slightly evoked the cellular senescence in HCT-116 p53?/? cells.ABT-263 significantly increased most of them, which was augmented by metformin in HCT-116 p53+/+ cells. However, these SASP components were unchanged or just mildly increased upon metformin/ABT-263 cotreatment in HCT-116 p53?/? cells. |
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Regulatory relationship
| Target gene experiment: |
SA-β-gal activity assay |
| Target gene description: |
We found that the metformin/ABT-263 cotreatment induced an obvious cellular senescence in HCT-116 p53+/+ cells, whereas the cotreatment only slightly evoked the cellular senescence in HCT-116 p53?/? cells. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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