External factors
| External factors: |
Doxorubicin |
| Category: |
Chemical compounds |
| Phenotype: |
Colorectal cancer |
| Experimental category: |
HL |
| Experiment: |
SA-β-gal activity assay//Knockdown |
| Description: |
Doxorubicin induced senescence in a largely p53-dependent manner in HCT116 cells; significantly more senescent cells were observed in HCT116 p53+/+ cells treated with Doxorubicin compared with HCT116 p53?/? cells treated with Doxorubincin . |
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Regulatory relationship
| Target gene experiment: |
SA-β-gal activity assay//Knockdown |
| Target gene description: |
Doxorubicin induced senescence in a largely p53-dependent manner in HCT116 cells; significantly more senescent cells were observed in HCT116 p53+/+ cells treated with Doxorubicin compared with HCT116 p53?/? cells treated with Doxorubincin . |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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