External factors
| Category: |
Chemical compounds |
| Phenotype: |
Colorectal cancer |
| Experiment: |
SA-β-gal activity assay//Flow cytometry |
| Description: |
SA β-galactosidase-stained HCT116 cells increased by 4.3- and 6.7-fold after treatment with 5 and 10 μM PTP, respectively, for 6 days. The cell cycle analysis revealed that HCT116 cells were arrested at the G1 phase of the cell cycle after 24 h of exposure to 10 μM PTP. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Target gene experiment: |
Western blot |
| Target gene description: |
Treatment with 10 M PTP increased the p53 protein level in a time-dependent manner in HCT116 cells expressing wild-type p53. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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