External factors
| External factors: |
low-Dox |
| Category: |
Chemical compounds |
| Experiment: |
Cell morphological analysis |
| Description: |
At concentrations of 100 ng/ml, doxorubicin (low-Dox) caused senescent morphology, whereas 500 ng/ml of doxorubicin (high-DOX) caused slim cell morphology. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Target gene experiment: |
Western blot |
| Target gene description: |
At concentrations that caused senescence (100 ng/ml), DOX induced low levels of p53 and did not inhibit S6 phosphorylation, a marker of mTOR activity. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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