External factors
| External factors: |
Pigment epithelium-derived factor |
| Experiment: |
SA-β-gal activity assay |
| Description: |
Most of the normoxic cultured-cells were positive for SA-β-gal after ceasing to proliferate,whereas few were stained in the other culture at the same time, which was a highly significant difference. |
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
383
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
383
Regulatory relationship
| R-EF-Target gene:
|
Downregulation//Downregulation |
| Official symbol(s): |
P53//P16 |
| Target gene experiment: |
Western blot |
| Target gene description: |
Consistent with previous findings, the levels of p53 and p16 increased with the lifespan of normoxic cultured-MSCs. In contrast, PEDF lowered the overall transcript level and protein expression of p53 and p16 by Day 95. |
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
471
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
472
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 751
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 754
Warning: Undefined variable $pathway_id in /data/html/Aging-ReG/public/browse_detail_2.php on line 793