External factors
| External factors: |
TC-G 1008 |
| Category: |
Chemical compounds |
| Phenotype: |
Osteoarthritis |
| Cell name: |
SW 13 53,Caco-2 |
| Experiment: |
SA-β-gal activity assay//Flow cytometry |
| Description: |
SA-β-gal activity assay:The specific GPR39 agonist TC-G 1008 ameliorates IL-1β-induced SA-βgal activity.Flow cytometry:The specific GPR39 agonist TC-G 1008 reduces IL-1b-induced cell cycle arrest in the G1 phase. |
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Regulatory relationship
| Target gene:
|
P53//P21//PAI-1 |
| R-EF-Target gene:
|
Downregulation//Downregulation//Downregulation |
| Official symbol(s): |
P53//P21//SERPINE1 |
| Target gene experiment: |
RT-PCR//Western blot |
| Target gene description: |
RT-PCR//Western blot:The specific GPR39 agonist TC-G 1008 attenuates the expression of p53, p21, and PAI-1 induced by IL-1b in human primary chondrocytes. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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