External factors
| External factors: |
Aldosterone |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
An increase in SA-β Gal staining, which is typically observed in senescent cells, was detected in the kidney, particularly the proximal tubules, of aldosterone-infused rats,but not in vehicle-infused rats. Aldosterone (1 and 10 nmol/liter for 3 d)dose-dependently increased the percentage of SA-β Gal–expressing HPTCs compared with vehicle treatment in both TSIm-HPTCs and N-HPTCs . |
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Regulatory relationship
| Target gene:
|
P53//P21//SIRT1 |
| R-EF-Target gene:
|
Upregulation//Upregulation//Downregulation |
| Official symbol(s): |
P53//P21//SIRT1 |
| Target gene experiment: |
RT-PCR//Western blot |
| Target gene description: |
Aldosterone infusion markedly increased the expression of p53 mRNA and protein.Aldosterone strongly increased the expression of p21 mRNA and protein.On the other hand, the gene expression of SIRT1, an enzyme that inactivates p53 by deacetylation, was reduced in aldoste-rone-infused rats compared with that in vehicle-infused rats. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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