External factors
| Category: |
Chemical compounds |
| Phenotype: |
Cardiovascular disease |
| Tissue type: |
Umbilical cord |
| Experiment: |
SA-β-gal activity assay//Western blot//CCK-8 assay |
| Description: |
Continuous exposure to 80 μg/ml ox-LDL for 24 h decreased the proliferation of HUVECs, up-regulated the expression of PAI-1 and P21, increased the ratio of cells in G0/G1 phase and positive cells of SA-β-gal staining compared with the control group. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation//Downregulation |
| Official symbol(s): |
P62//SIRT1 |
| Target gene experiment: |
Western blot |
| Target gene description: |
Ox-LDL also decreased the ratio of LC3 II/LC3 I, increased the protein level of p62 and decreased the expression of SIRT1 in a dose-dependent manner. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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