External factors
| External factors: |
Indoxyl sulfate |
| Category: |
Chemical compounds |
| Phenotype: |
Chronic kidney disease |
| Experiment: |
SA-β-gal activity assay |
| Description: |
IS significantly increased the percentage of SA β-gal-positive cells, as scored by counting the numbers of blue and total cells, compared to that observed in the control cells at 24 hours. |
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Regulatory relationship
| Official symbol(s): |
Warning: Undefined variable $name_all in /data/html/Aging-ReG/public/browse_detail_2.php on line 525
AHR
|
| Pathway experiment: |
SA-β-gal activity assay//HDAC colorimetric assay//Immunoblotting |
| Pathway description: |
Pretreatment with ANF (10 μmol/L) or CH223191 (10 μmol/L)39), AhR inhibitors, for one hour rescued the IS-induced cellular senescence in the HUVECs. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.