External factors
| External factors: |
Ascorbic acid |
| Aging characteristic: |
Others |
| Category: |
Chemical compounds |
| Experiment: |
Western blot//SA-β-gal activity assay |
| Description: |
The increased expression of p16 induced by D-gal could be reduced when treated with ascorbic acid (AA).After adding AA,the SA-β-gal positive cells ratio could be decreased compared to D-gal only group. |
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Regulatory relationship
| Regulatory pathway:
|
Akt-mTOR |
| R-EF-Pathway:
|
Downregulation |
| Official symbol(s): |
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AKT1-MTOR
|
| Pathway experiment: |
Western blot |
| Pathway description: |
Activation of AKT/mTOR signaling pathway was increased in the Dgal group, and weakened when AA was added . |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.