External factors
| Aging characteristic: |
Others |
| Category: |
Chemical compounds |
| Experiment: |
CCK-8 assay assay//Western blot//SA-β-gal activity assay |
| Description: |
We found that cell survival rate was inhibited by D-gal in a time- and dose-dependent manner.The expression of p16 was gradually increased as the concentration raised.We found that SA-β-gal positive cells ratio was obviously increased by D-gal stimulation. |
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Regulatory relationship
| Regulatory pathway:
|
Akt-mTOR |
| R-EF-Pathway:
|
Upregulation |
| Official symbol(s): |
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AKT1-MTOR
|
| Pathway experiment: |
Western blot |
| Pathway description: |
The expressions of p-AKT and p-mTOR were promoted by D-gal in a timeand dose-dependent manner. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.