External factors
| External factors: |
Metformin |
| Category: |
Chemical compounds |
| Experimental category: |
HL |
| Description: |
Moreover, a declined p16 and p53 expression was also detected in the metformin-treated group, indicating that the senescence characteristics of the endogenous Alpl+/- MSCs were rescued by the metformin treatment. |
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Regulatory relationship
| Official symbol(s): |
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AMPK
|
| Pathway experiment: |
Western blot |
| Pathway description: |
The expression levels of p-AMPKα and p-ACC were elevated in the Alpl+/- MSCs after the metformin injections . |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.