External factors
| External factors: |
Metformin |
| Category: |
Chemical compounds |
| Phenotype: |
Hepatocellular carcinoma |
| Tissue type: |
Tumor tissue |
| Experiment: |
SA-β-gal activity assay//Immunostaining |
| Description: |
The SA-β-gal staining was significantly higher in the treated group than in the control group.immunohistochemical analysis of the harvested tumors revealed increased DEC1 expression compared with the control animals. |
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Regulatory relationship
| Regulatory pathway:
|
AMPK-SIRT1 |
| Official symbol(s): |
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AMPK-SIRT1
|
| Pathway experiment: |
Immunostaining//Western blot |
| Pathway description: |
Immunohistochemistry analysis revealed increased positive staining of pAMPK at Thr-172, pSIRT1 at Ser-47, acetylated-p53 at Lys382 (Ac-p53) and p21 in harvested tumors from low-dose-metformin-treated animals compared with control animals , which is consistent with the western blot analysis results. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.