External factors
| Phenotype: |
Cervical cancer |
| Experimental category: |
HL |
| Experiment: |
SA-β-gal activity assay//Western blot |
| Description: |
20A treatment resulted in a dose-dependent increase in the percentage of cells stained for β-galactosidase,suggesting that 20A causes senescence. 20A treatment elicited a significant time-dependent up-regulation of both p21 and p27 proteins in HeLa cells. |
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Regulatory relationship
| Official symbol(s): |
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ATM
|
| Pathway experiment: |
SA-β-gal activity assay//Western blot |
| Pathway description: |
Loss of ATM significantly reduced senescence induced by 20A, irrespective of the presence or absence of p53 protein .The inhibition of ATM activation by KU55933 prevented 20A-induced accumulation of LC3-II. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.