External factors
| External factors: |
BIBR1532 |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Flow cytometry |
| Description: |
After a total dose of 8 Gy of conventional fractionation radiation (2 Gy over 4 fractions), SA-β-gal-positive cells were significantly increased when cells were treated with BIBR1532 . BIBR1532 significantly decreased IR-induced G2/M cell cycle arrest after irradiation in both non-small cell lung cancer (NSCLC) cell lines. |
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Regulatory relationship
| Regulatory pathway:
|
ATM-CHK1 |
| R-EF-Pathway:
|
Downregulation |
| Official symbol(s): |
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ATM-CHK1
|
| Pathway experiment: |
Western blot//Flow cytometry |
| Pathway description: |
In NSCLC cells, BIBR1532 significantly inhibited radiation-induced ATM/CHK1 phosphorylation.BIBR1532 treatment also inhibited IR-induced G2/M cell cycle arrest. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.