External factors
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
SA-β-gal activity significantly(p＜0.05) enhanced in H2O2treated cells with over 60% cells appearing senescent as compared to control group, which was significantly (p＜0.05) abrogated on treatment with EGCG. |
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Regulatory relationship
| Regulatory pathway:
|
Bcl-2 |
| R-EF-Pathway:
|
Downregulation |
| Official symbol(s): |
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BCL2
|
| Pathway experiment: |
Western blot |
| Pathway description: |
Assessment of underlying molecular mechanism for apparent senolytic effects of EGCG revealed a strong upregulation of Bcl-2 protein expression in senescent cells which was dose dependently and significantly (p＜0.05) abrogated by EGCG treatment. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.