External factors
| External factors: |
HCV infection |
| Experiment: |
SA-β-gal activity assay |
| Description: |
SA-β-gal expression increased in senescent CD4+ T cells in HCV-infected patients compared with age-matched HS. |
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Regulatory relationship
| Regulatory pathway:
|
DNp63-miR18-1a-SIRT1 |
| Official symbol(s): |
Warning: Undefined variable $name_all in /data/html/Aging-ReG/public/browse_detail_2.php on line 525
YAP1-SIRT1
|
| Pathway experiment: |
Flow cytometry//Western blot//RT-PCR |
| Pathway description: |
The protein levels of Sirt1 were significantly upregulated in CD4+T cells from 22 HCV-infected patients compared with 22 age-matched HS；We then silenced the expression of DNp63 in CD4+T cells from patients with HCV and found that lower expression of DNp63 in T cells by transfecting its specific siRNA led to an up-regulation of miR-181a and a down-regulation of Sirt1 expression. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.