External factors
| External factors: |
Cisplatin |
| Category: |
Chemical compounds |
| Phenotype: |
Esophageal cancer |
| Experiment: |
SA-β-gal activity assay |
| Description: |
Cisplatin significantly elevated cellular senescence in EC109 cells in a time-dependent manner. |
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Regulatory relationship
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
471
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
472
| Regulatory pathway:
|
ERK1/2 |
| Pathway experiment: |
SA-β-gal activity assay//Western blot//PI staining//Annexin V binding assay |
| Pathway description: |
Treatment of cisplatin obviously stimulated the phosphorylation of ERK1/2, p38, and JNK.inhibition of ERK1/2 significantly suppressed cisplatin-induced apoptosis and senescence in EC109 and EC109/CDDP cells . |
Aging network
Warning: Undefined array key 1 in
/data/html/Aging-ReG/public/browse_detail_2.php on line
578
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Pathway view
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
751
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
754
Warning: Undefined variable $pathway_id in
/data/html/Aging-ReG/public/browse_detail_2.php on line
793