External factors
| External factors: |
Oxytocin |
| Category: |
Chemical compounds |
| Experimental category: |
HL |
| Experiment: |
SA-β-gal activity assay//Western blot//Knockdown |
| Description: |
OXTR knockdown or treatment with a MAPK kinase (MEK) inhibitor completely abolished the ability of OT to prevent the SASP-induced cellular senescence, as indicated by increased SA-β-Gal positive rate, upregulated levels of p21 and p16, and diminished cell proliferation. |
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Regulatory relationship
| Regulatory pathway:
|
ERK-Nrf2 |
| Official symbol(s): |
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ERK-NFE2L2
|
| Pathway experiment: |
SA-β-gal activity assay//Western blot//Knockdown |
| Pathway description: |
OT enhanced nuclear accumulation of Nrf2 in a dose-dependent manner . This was reversed by OXTR silencing or treatment with MEK inhibitor .Knockdown of Nrf2 completely abrogated the beneficial effects of OT on SASP-induced senescence . |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Related pathway view