External factors
| External factors: |
pIFN- α |
| Category: |
Chemical compounds |
| Tissue type: |
Tumor tissue |
| Experiment: |
SA-β-gal activity assay//Cell morphological analysis |
| Description: |
We observed that upon exposure to pIFN-α,cells became enlarged, flattened, irregularly shaped and significantly more cells expressed SA β-gal+, suggesting a senescent phenotype as compared with untreated cell cultures. |
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Regulatory relationship
| Regulatory pathway:
|
IRF-1 |
| Official symbol(s): |
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IRF1
|
| Pathway experiment: |
Western blot |
| Pathway description: |
Interestingly, treatment with 0.25 or 0.5 mg/ml pIFN-a induced the same level of IRF-1. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.